Effects of cigarette smoking on iodine 123N-isopropyl-p-iodoamphetamine clearance from the lung
✍ Scribed by Kunihiko Kato; Satoshi Harada; Tsuneo Takahashi; Shigehiko Katsuragawa; Toru Yanagisawa
- Book ID
- 104652062
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 457 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0340-6997
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✦ Synopsis
Iodine 123 N-isopropyl-p-iodoamphetamine (tz3I-IMP), originally developed as a brain scanning agent, is also taken up by the lung. To evaluate the effects of cigarette smoking on the kinetics of IMP in the lung, we studied 123I-IMP clearance from the lung in 18 volunteers (8 non-smokers and 10 smokers). After the injection of 111 MBq of 123I-IMP into the medial cubital vein, the time-activity curve for 60 rain and the regional activity using 1 frame per minute and a 64 x 64 matrix were obtained. The 123I-IMP clearance curve was described as follows: C(t)=A~e k,t+A2e ~2t(A1,A2: intercepts, and k~, k2: slopes of the exponential components). 123I-IMP clearance was delayed in smokers, and kz was smaller in smokers. Also, a correlation between k~, k2, and the number of cigarettes smoked per day was found (r = -0.65, r = -0.74, respectively, P < 0.01). In conclusion, this study suggests that the delayed clearance and retention of 123I-IMP in the lung indicate lung metabolic disorders due to cigarette smoking.