Effects of chronic stress on contextual fear conditioning and the hippocampal expression of the neural cell adhesion molecule, its polysialylation, and L1
โ Scribed by C Sandi; J.J Merino; M.I Cordero; K Touyarot; C Venero
- Book ID
- 117489932
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 295 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0306-4522
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The neural cell adhesion molecule L1 is a cell surface glycoprotein of the immunoglobulin superfamily which mediates adhesion between neural cells. The possibility that similar cell-cell recognition mechanisms may be shared by the nervous and immune systems prompted us to study the expression and fu
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## Abstract L1 is critically involved in neural development and maturation, activityโdependent synaptic plasticity, and learning processes. Among adult rats, chronic stress protocols that affect L1 functioning also induce impaired cognitive and neural functioning and heightened anxiety reminiscent