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Effects of chronic intraventricular infusion of heparin glycosaminoglycan on learning and brain acetylcholine parameters in aged rats

✍ Scribed by Karel Jezek; Daniela Schulz; Maria Angelica De Souza Silva; Hans-Werner Müller; Joseph P. Huston; Rüdiger U. Hasenöhrl

Book ID
117345619
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
155 KB
Volume
147
Category
Article
ISSN
0166-4328

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## Abstract Oral and intraperitoneal administration of the nucleoside guanosine have been shown to prevent quinolinic acid‐ (QA) and α‐dendrotoxin‐induced seizures, impair memory, and impair anxiety in rats and mice. We investigated the effect of 2‐weeks ad lib orally administered guanosine (0.5 mg