Effects of choline and acetylcholine chloride upon peripheral nerve fibers
✍ Scribed by De Nó, Rafael Lorente
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1944
- Tongue
- English
- Weight
- 876 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0095-9898
No coin nor oath required. For personal study only.
✦ Synopsis
SEVEN FIGURES
Acetylcholine, a substance which even when employed in minute concentrations, exerts a powerful excitatory action at certain synaptic * The purity of the drug (Merck) was tested with the eserinized leech preparation. It produced contraction of the leech muscle at the concentration lo-'%.
'It is o f interest t o note that dthouah a 0.1 M solution of potassium chloride produces a total conduction block usually within 10 to 15 minutes, it is a slowly depolarizing agent, to the extent that the demarcation potential never reaches a maximum in less than 300 t o 500 minutes, and not infrequently the demarcation potential has been observed t o increase continuously throughout 1000 minutes. The upper rurve in figure 1 is typical for bullfrog sciatic nerve at 20" to 25°C. When the effect of anoxia is added t o that of potassium chloride (0.1 M), total depolarization of the nerve membrane is obtained in about 200 minutes or slightly longer.