Effects of chlorpromazine and three metabolites on behavioral responses in rats

✍ Scribed by Herbert Barry; Marie L. Steenberg; Albert A. Manian; Joseph P. Buckley

• Publisher: Springer
• Year: 1974
• Tongue: English
• Weight: 600 KB
• Volume: 34
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00422558

✦ Synopsis

Effects of chlorpromazine (CPZ) and three metabolites (3,7-dihydroxy-CPZ; 7,8-dihydroxy-CPZ; 7-hydroxy-CPZ) on behavioral performance of rats were tested by three methods: (a) continuous nondiseriminative lever-pressing shockavoidance response without a warning signal; (b) discriminative pole-climbing shock avoidance and escape; (c) discriminative control of behavior by drug states. Both types of avoidance were much more impaired by CPZ than by the metabolites. The metabolite producing the most consistent'impairment was 7-hydroxy-CPZ and the least consistent was 7,8-dihydroxy-CPZ. In the test for discriminative control of behavior by drug states, the 7-hydroxy-CPZ was the only metabolite which evoked the CPZ stimulus characteristics whereas the 7,8-dihydroxy-CPZ produced a generalized depressant effect.