Effects of chlordiazepoxide, buspirone, and serotonin receptor agonists and antagonists on responses of squirrel monkeys maintained under second-order schedules of intramuscular cocaine injection or food presentation
✍ Scribed by Michael A. Nader; James E. Barrett
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 859 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0272-4391
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✦ Synopsis
Nader, M.A. and J.E. Barrett: Effects of chlordiazepoxide, buspirone, and serotonin receptor agonists and antagonists on responses of squirrel monkeys maintained under second-order schedules of intramuscular cocaine injection or food presentation. Drug Dev.
Res. 20:5-17, 1990.
Lever pressing of squirrel monkeys was maintained under second-order schedules of either food presentation or cocaine injection. The first response after 3 min produced a 2 sec change in the color of a visual stimulus; the tenth stimulus presentation was followed by either an i.m. injection of cocaine (0.3, 1.0, or 2.0 mgikg) or the delivery of food. The benzodiazepine chlordiazepoxide (0.3-5.6 mgikg) increased responding maintained by food at doses that decreased cocaine-maintained responding. In contrast, buspirone, a novel nonbenzodiazepine anxiolytic (0.001 -0.03 mgikg), its analog gepirone (0.003-0.03 mg/kg), and the N serotonin 1 A (5-HTlA) agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT; 0.0003-0.001 mgikg) increased cocaine-maintained responding at doses that decreased responding maintained by food. The inverse agonist at benzodiazepine receptors ~-carboline-3-carboxylic acid ethyl ester (PCCE) only decreased response rates irrespective of the maintaining event. m-Chlorophenylpiperazine (mCPP), an agonist at 5-HTl