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Effects of chloilde channel stereospecific activator and inhibitor on myotonic mouse skeletal muscle fibers

✍ Scribed by M. Mambrini; D. Tricarico; H. Jockusch; D. Conte Camerino; V. Tortorella

Book ID: 115884956
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 217 KB
Volume: 183
Category: Article
ISSN: 0014-2999
DOI: 10.1016/0014-2999(90)93126-b

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## Abstract Myotonic muscular dystrophy (DM) is characterized by abnormal skeletal muscle Na channel gating and reduced levels of myotonic dystrophy protein kinase (DMPK). Electrophysiological measurements show that mice deficient in __Dmpk__ have reduced Na currents in muscle. We now find that the