Abnormal adhesion of sickle cells to vascular endothelium may be a factor in the initiation of painful vaso-occlusive crisis. The sickle cell population contains an unusually large number of less dense reticulocytes that are known to be more adhesive than mature red cells, but there is contradictory
Effects of catechins on the mouse lung carcinoma cell adhesion to the endothelial cells.
โ Scribed by Mamoru Isemura; Yasuo Suzuki; Ken Satoh; Koh Narumi; Masakichi Motomiya
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 451 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1065-6995
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
We studied the effects of 5 kinds of catechins on the adhesion of mouse lung carcinoma 3LL cells to the monolayer of bovine lung endothelial cells. (โ)โEpicatechin gallate and (โ)โepigallocatechin gallate were active in inhibiting the 3LL cell adhesion, while (+)โcatechin and (โ)โepicatechin were inactive. (โ)โEpigallocatechin showed a considerable cytotoxicity. These data suggest that the specific chemical structure is required to exert the inhibitory activity of catechins and the search for the cellular binding protein(s) bound to these inhibitory catechins would provide a clue to clarify the mechanism of interactions between tumor cells and endothelial cells.
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