Effects of casein, sweet white lupin and sweet yellow lupin diet on cholesterol metabolism in rats

✍ Scribed by Chango, Abalo; Villaume, Christian; Bau, Hwei Ming; Schwertz, Annie; Nicolas, Jean-Pierre; Mejean, Luc

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 180 KB
• Volume: 76
• Category: Article
• ISSN: 0022-5142
• DOI: 10.1002/(sici)1097-0010(199802)76:2<303::aid-jsfa961>3.0.co;2-#

✦ Synopsis

The e †ect of lupin seed protein on rat cholesterol metabolism has been studied with diets high in fat (20% by weight) and containing cholesterol (1%). The proteins used were characterised by their lysine/arginine ratios (sweet white lupin (SWL) 0É5 ; sweet yellow lupin (SYL) 0É4 ; and casein 1É8), because the lysine/arginine ratio is one of the parameters suspected to decrease or increase plasma cholesterol depending on the ratio ; the diets were also characterised by their total Ðbre content (casein diet 5% ; SWL 22% ; SYL 17%) because chronic Ðbre intake could improve glucose tolerance and modify glucoregulatory hormone levels. Methionine content of diets was balanced. Di †erences among the total serum cholesterol levels of rat groups fed these diets for 28 days were not signiÐcant. But, compared to the casein diet, both lupin diets increased plasma glucagon levels and faeces. Compared to casein and SYL diets, the SWL diet signiÐcantly decreased plasma triglyceride levels and the insulin/glucagon ratio, as well as unesteriÐed liver cholesterol and plasma LDL triglycerides levels. The SYL diet signiÐcantly increased plasma glucose and insulin, as well as liver total cholesterol compared to the casein and SWL diets. The total Ðbre content of the diets could indirectly modulate the e †ect related to the insulin/glucagon ratio on cholesterol metabolism and explain the di †erences observed between the SWL and SYL diets.

1998 SCI.