Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum
✍ Scribed by F. López-Redondo; G. M. Lees; R. G. Pertwee
- Book ID
- 110003174
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 309 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0007-1188
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## Abstract The synaptic input on myenteric Dogiel type II neurones (n = 63) obtained from the ileum of 17 pigs was studied by intracellular recording. In 77% of the neurones, electrical stimulation of a fibre tract evoked fast excitatory postsynaptic potentials (fEPSPs) with an amplitude of 6 ± 5
Responses of gastric myenteric neurones evoked by the mammalian tachykinins substance P (SP), neurokinin A (NKA) and neurokinin B (NKB) were investigated using conventional intracellular recording methods. Application of the tachykinins caused a long lasting depolarization of the membrane potential