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Effects of Camptothecin Analogues on DNA Transformations Mediated by Calf Thymus and Human DNA Topoisomerases I

✍ Scribed by Wang, Xiangyang; Short, Glenn F.; Kingsbury, William D.; Johnson, Randall K.; Hecht, Sidney M.


Book ID
126271288
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
134 KB
Volume
11
Category
Article
ISSN
0893-228X

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Calf thymus DNA-Topoisomerase I activity was found to be altered by changing in phosphorylation: it was completely inhibited upon dephosphorylation by alkaline phosphatase, but incubation with N II protein kinase and ATP restored the relaxation activity to a level higher than that observed prior to