Effects of caffeine and 2,3-butanedione monoxime (BDM) on contractile properties of skinned cardiac fibres from normal and diabetic rats
β Scribed by N. Khandoudi; J.M. Chesnais; D. Feuvray
- Book ID
- 115982309
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 97 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2828
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2,3-butanedione 2-monoxime (BDM) inhibits muscle contraction and actomyosin ATPase both in fibres and in solution. It is potentially useful as a tool for exploring weak interactions between actin and myosin. We have examined the effect of BDM on several key steps of the myosin subfragment-1 and acto
The effects of 2,3-butanedione monoxime (BDM) were studied in smooth muscle fibres from guinea pig taenia colt. In intact muscle, active force during contractions induced by high-K + was inhibited by about 10% in I mM BDM and by approximately 70% in 10 mM BDM. Intracellular [Ca 2+ ] during contracti