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Effects of Ca2+ entry blockers on kainate-induced changes in extracellular amino acids and Ca2+ in vivo

✍ Scribed by J. W. Lazarewicz; A. Lehmann; A. Hamberger

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
348 KB
Volume
18
Category
Article
ISSN
0360-4012

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✦ Synopsis

The effect of organic Ca2' channel blockers and Co2+ on kainate-induced changes in 45Ca2+ eMux and amino acid release was studied in the rabbit hippocampus with the dialysis-perfusion technique. Administration of 1 mM kainate caused a transient, 50% drop of extracellular Ca2'. This effect was insensitive to 100 pM flunarizine or verapamil, 10 pM nimodipine, and 6 mM CoCl2. The organic Ca2' entry blockers did not significantly influence kainate-induced changes in extracellular amino acids, whereas Co2' affected both basal and kainic acid stimulated release of amino acids. These results indicate that kainate-regulated Ca2+ ionophores differ from Ca2+ channels in peripheral tissues in terms of sensitivity to Ca2' entry inhibitors.

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