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Effects of C2-Alkylation, N-Alkylation, and N,N‘-Dialkylation on the Stability and Estrogen Receptor Interaction of (4R,5S)/(4S,5R)-4,5-Bis(4-hydroxyphenyl)-2-imidazolines

✍ Scribed by von Rauch, Moriz; Schlenk, Miriam; Gust, Ronald


Book ID
115451269
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
357 KB
Volume
47
Category
Article
ISSN
0022-2623

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Amino-3~5-bis(1-hydroxyethyl)-l,2,4-triazole 2 (SAT) (from (S)-lactic acid and hydrazine hydrate) reacted with substituted benzaldehydes 6 to afford N-[(S,S)-3,5-bis(1hydroxyethyl)-l,2,4-triazol-4-yl]arylimines 3 in excellent yield. Protection of the hydroxyl groups in compounds 3 was accomplished u