Bone morphogenetic proteins (BMPs) are factors that promote osteoblastic cell differentiation and osteogenesis. It is unknown whether BMPs may act on human osteoblastic cells by increasing immature cell growth and/or differentiation. We investigated the short- and long-term effects of recombinant hu
Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report
β Scribed by Hiroshi Orui; Satoshi Imaizumi; Toshihiko Ogino; Teiichi Motoyama
- Publisher
- Springer Japan
- Year
- 2000
- Tongue
- English
- Weight
- 62 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0949-2658
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Osteoprogenitor cells in the human bone marrow stroma can be induced to differentiate into osteoblasts under stimulation with hormonal and local factors. We previously showed that human bone marrow stromal (HBMS) cells respond to dexamethasone and vitamin D by expressing several osteoblastic markers
Recombinant human bone morphogenetic protein-2 (rhBMP-2) is known to induce orthotopic and ectopic bone formation in vivo. Several in vitro studies using rat or mouse clonal cell lines have shown that rhBMP-2 may be involved in the differentiation of osteoblasts from osteoblast precursor cells or st
We have examined the effects of BMP-2 on the expression of bone matrix proteins in both human bone marrow stromal cells (HBMSC) and human osteoblasts (HOB) and their proliferation and mineralization. Both HBMSC and HOB express BMP-2/-4 type I and type II receptors. Treatment of these two cell types
## Abstract Bone morphogenetic proteins (BMP) stimulate osteoblast differentiation by signal transduction via three BMP receptors (BMPRβIA, βIB, and βII). Several growth factors, including transforming growth factorβΞ²1 (TGFβΞ²1), fibroblast growth factorβ2 (FGFβ2) and plateletβderived growth factorβ