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Effects of benzo(a)pyrene adducts on DNA synthesis in vitro

✍ Scribed by Izumi Yamaura; Hans Marquardt; Liebe F. Cavalieri

Book ID
113135933
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
551 KB
Volume
23
Category
Article
ISSN
0009-2797

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✍ Mette Tingleff Skaanild; JΓΈrgen Clausen πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 English βš– 596 KB

Polycyclic aromatic hydrocarbons, e.g., benzo[a]pyrene (B(a)P) are known carcinogens/mutagens. These compounds may be metabolized by the P450 mixed function monooxygenase to more nucleophilic compounds which may form adducts to the cellular macromolecules, e.g., DNA, RNA, and proteins. We have used