Effects of bacillus calmette-guerin on cytotoxic activities of peripheral blood lymphocytes against human T24 lined and freshly isolated autologous urinary bladder transitional carcinoma cells in patients with urinary bladder cancer
✍ Scribed by Youichi Mizutani; Yoshinori Nio; Manabu Fukumoto; Osamu Yoshida
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 867 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
The effects of bacillus Calmette-Guerin (BCG) on the cytotoxic activities of peripheral blood lymphocytes against human T24 lined and freshly separated autologous urinary bladder transitional carcinoma cells in patients with urinary bladder cancer were analyzed in a 12-hour chromium 51 ( 51Cr) release assay. The results of this study indicate that BCG activates the tumor killing system through stimulation of effector cells and elevation of target cell susceptibility in patients with urinary bladder cancer, suggesting that BCG-augmented cytotoxicity may be oriented specifically to urinary bladder cancer cells. This could explain the remarkable clinical benefits of intravesical instillation of BCG against urinary bladder cancer. Cancer 1992; 69:537-545.
Intravesical instillation of bacillus Calmette-Guerin (BCG) is an established and effective therapy for superficial urinary bladder cancer.',' The antitumor effects of BCG seem to be related to immunologic mechanisms, although its mode of action is still ~n k n o w n . ~, ~ Previous studies in animals have suggested that host immuno-