Effects of artilide on spontaneous and induced ventricular arrhythmias in 24-hour canine myocardial infarction

✍ Scribed by Lewis V. Buchanan; Glenn Kabell; Uta M. Turcotte; Marshall N. Brunden; John K. Gibson

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 575 KB
• Volume: 30
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430300105

✦ Synopsis

The electrophysiologic and antiarrhythmic effects of artilide were evaluated in dogs 24 h after myocardial infarction. Artilide (0.1 to 3.0 mgikg or 0.2 to 7.0 p,M/kg iv) prevented programmed stimulation induced ventricular arrhythmias in 9 out of 9 dogs that had demonstrated inducible ventricular arrhythmias prior to treatment. This antiarrhythmic action was associated with significant increases in ventricular refractoriness and monophasic action potential duration. Lower doses of artilide tended to reduce the incidence of spontaneous ventricular arrhythmias but these effects were not significant. These results are consistent with the concept that spontaneous and pacing induced ventricular arrhythmias result from different mechanisms, and that class Ill antiarrhythmic agents are more effective in suppressing induced ventricular tachycardia due to reentry than spontaneous arrhythmias which result from nonreentrant mechanisms. o 1993 WiIey-Liss, inc.