Effects of Aromatic Substituents on Binaphthyl-Based Chiral Spiro-Type Ammonium Salts in Asymmetric Phase-Transfer Reactions

✍ Scribed by Taichi Kano; Quan Lan; Xisheng Wang; Keiji Maruoka

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 354 KB
• Volume: 349
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.200600576

✦ Synopsis

Abstract

Spiro‐type phase‐transfer catalysts prepared from two equivalents of a single binaphthyl subunit were designed and applied to the asymmetric alkylation and direct aldol reactions of a glycine derivative. The effects of the substitution pattern of the binaphthyl subunits on the enantioselectivity were also investigated.