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Effects of aripiprazole on MK-801-induced prepulse inhibition deficits and mitogen-activated protein kinase signal transduction pathway

✍ Scribed by Daisuke Ishii; Daisuke Matsuzawa; Nobuhisa Kanahara; Shingo Matsuda; Chihiro Sutoh; Hiroyuki Ohtsuka; Ken Nakazawa; Mami Kohno; Kenji Hashimoto; Masaomi Iyo; Eiji Shimizu


Book ID
116772014
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
365 KB
Volume
471
Category
Article
ISSN
0304-3940

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Synovial fluid basic calcium phosphate (BCP) crystals are markers of severe joint degeneration in osteoarthritis. These crystals are mitogenic and induce protooncogene expression and matrix metalloproteinase (MMP) synthesis and secretion in human fibroblasts, effects that are specifically blocked by