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Effects of Ara-C on neutral sphingomyelinase and mitogen-and stress-activated protein kinases in T-lymphocyte cell lines

โœ Scribed by Cynthia D. Bradshaw; Krishna M. Ella; Aydrian L. Thomas; Chen Qi; Kathryn E. Meier


Book ID
111742052
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
612 KB
Volume
40
Category
Article
ISSN
1521-6543

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Multiple studies demonstrate that manganese (Mn) exposure potentiates inflammatory mediator output from activated glia; this increased output is associated with enhanced mitogen activated protein kinase (MAPK: p38, ERK and JNK) activity. We hypothesized that Mn activates MAPK by activating the kinas