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Effects of apomorphine on flexor reflex and periodic limb movement

✍ Scribed by Guillermo Paradiso; Farooq Khan; Robert Chen

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 62 KB
Volume: 17
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.1254

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✦ Synopsis

It has been suggested that periodic leg movements (PLM) and spinal flexor reflex (FR) share common mechanisms. Although dopaminergic agents improve PLM in humans and strongly influence spinal FR circuitry in animal studies, its effects on FR have not been documented in humans. We describe a 65-year-old man with PLM after overnight withdrawal of dopaminergic agents. The electromyographic pattern of spontaneous PLM closely resembled that of the FR elicited by medial plantar nerve stimulation. Thirty minutes after subcutaneous injection of apomorphine, both PLM and FR were completely abolished. These findings demonstrate that dopaminergic agents can suppress exaggerated FR in humans, and support the hypothesis of common mechanisms for PLM and FR.

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