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Effects of Ape1 Overexpression on Cellular Resistance to DNA-Damaging and Anticancer Agents

✍ Scribed by Laura J. Schild; Kerry W. Brookman; Larry H. Thompson; David M. Wilson

Book ID
110392163
Publisher
Springer
Year
1999
Tongue
English
Weight
1022 KB
Volume
25
Category
Article
ISSN
1572-9931

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Transcriptional activation of c-fos in response to both serum stimulation and D N A damage requires the serum response element. The inability of in vitro aged or senescent fibroblasts to proliferate in response to serum has been shown to be associated with repressed c-fos expression and reduced AP-1