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Effects of antirheumatic drugs on the interleukin-1α induced synthesis and activation of proteinases in articular cartilage explants in culture

✍ Scribed by C. Arsenis; J. McDonnell

Publisher
SP Birkhäuser Verlag Basel
Year
1989
Tongue
English
Weight
239 KB
Volume
27
Category
Article
ISSN
1420-908X

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Inhibition of interleukin-1α-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: Potential role for matrix metalloproteinases in the generation of cartilage oligomeric matrix protein fragments in arthritic synovial fluid
✍ Vishwas Ganu; Ronald Goldberg; Jane Peppard; John Rediske; Richard Melton; Shou- 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 918 KB

Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti