This study describes the effects of penicillin G (PC-G) potassium, PC-G sodium, cloxacillin sodium (MCIPC), disodium sulbenicillin (SBPC), cefazolin sodium (CEZ) and cefsulodin sodium (CFS) on the in-vitro electroretinogram (ERG) of the albino rabbit.
The b-wave and oscillatory potentials (OPs) were unchanged by 0.1 mM PC-G potassium or PC-G sodium. The OPs were slightly suppressed by 0.3 mM of either drug. While the a-and b-waves were not deteriorated, the OPs were greatly suppressed by 1.0 mM concentration. The effect of PC-G on the ERG was characterized by a selective suppression of the OPs. The b-wave and OPs were not suppressed by 0.03 mM MCIPC. They were slightly suppressed by 0.05 mM MCIPC. The a-wave, b-wave and OPs were not deteriorated by 1.0 mM SBPC. The b-wave and OPs were suppressed by 3.0 mM or 6.0mM SBPC respectively. These changes appeared to be dose-dependent. Since the b-wave and OPs were concomitantly suppressed by both MCIPC and SBPC, these antibiotics, unlike PC-G, did not selectively suppress the OPs. The b-wave and OPs were unchanged by 0.1 mM CEZ or CFS. The OPs were slightly suppressed by 0.3mM CEZ or CFS. CEZ or CFS of 1.0raM did not deteriorate the a-and b-waves, but selectively suppressed the OPs. The effects of CEZ and CFS on the ERG were characterized by a selective suppression of the OPs. The above-described changes in the ERG were reversible.