Effects of Anesthetics on the Structure of a Phospholipid Bilayer: Molecular Dynamics Investigation of Halothane in the Hydrated Liquid Crystal Phase of Dipalmitoylphosphatidylcholine
β Scribed by Tu, Kechuan; Tarek, Mounir; Klein, Michael L.; Scharf, Daphna
- Book ID
- 119411512
- Publisher
- Biophysical Society
- Year
- 1998
- Tongue
- English
- Weight
- 625 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0006-3495
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π SIMILAR VOLUMES
In order to obtain a better description for the membrane area of a lipid bilayer, the potential parameter set OPLS, modified with respect to the interaction for the alkyl chain, was adopted for the present molecular dynamics simulation. A long-time and large-scale calculation based upon this modifie
Gossypol (1,1 ',6,6 ',7,7'-hexahydroxy-5,5 ' -diisopropyl-3,3 '-dimethyl[2,2'-binaphthalene]-8,8' dicarboxaldehyde) previously used as a male oral contraceptive is an amphiphilic compound. At low concentrations, it is expected that gossypol would intercalate into the phospholipid bilayers. To demons