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Effects of analogues of adenosine and methyl xanthines on insulin sensitivity in soleus muscle of the rat

✍ Scribed by Leszek Budohoski; R.A. John Challis; Bronwyn McManus; Eric A. Newsholme


Book ID
115915841
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
343 KB
Volume
167
Category
Article
ISSN
0014-5793

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The diuretic furosemide (0.5 mmol/l) impaired glucose uptake in the soleus muscle of the rat by decreasing the sensitivity of glycolysis to insulin. In addition, at higher concentrations (1.0 mmol/l) the drug inhibited the basal rate of glycolysis. It did not, however, inhibit the rate of glycogen s