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Effects of an alpha-2 adrenoceptor antagonist, Org 3770, upon the autonomic function of the pupil

✍ Scribed by E. Palazidou; J. M. A. Sitsen; S. A. Checkley

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 326 KB
Volume: 5
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470050207

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✦ Synopsis

The effects of a single oral dose of an alpha-2 adrenoceptor antagonist, Org 3770 (30mg), upon the autonomic function of the human pupil have been investigated in six volunteers. Org 3770 reduced pupil diameter, possibly as a result of its alpha-2 adrenoceptor blocking activity. Org 3770 did not reduce the mydriatric effect of phenylephrine and tyramine, nor was the miotic response to pilocarpine affected. These results are consistent with a blockade by Org 3770 of central alpha-2 adrenoceptors.

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