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Effects of amitriptyline and isocarboxazid on 5-hydroxytryptophan induced head twitches in mice

โœ Scribed by Mitsutaka Nakamura; Hideaki Fukushima; Sumio Kitagawa

Publisher
Springer
Year
1976
Tongue
English
Weight
350 KB
Volume
48
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

Effects of amitriptyline and isocarboxazid on brain 5-HT and 5-HIAA were examined in relation to their action on 5-HTP induced head twitches. Amitriptyline reduced 5-HTP induced head twitches but isocarboxazid increased them. Both amitriptyline and isocarboxazid caused a significant increase of brain 5-HT concentration in 5-HTP treated mice. Amitriptyline also caused a significant increase of 5-HIAA concentration, while isocarboxazid reduced 5-HIAA concentration in the brains of 5-HTP treated mice. Probenecid, which significantly increased 5-HIAA concentration without affecting brain 5-HT concentration in 5-HTP treated mice, reduced 5-HTP induced head twitches. These results suggest that 5-HTP induced head twitches might be induced by an increase of 5-HT concentration, and reduced by an increase of 5-HIAA or a decrease of 5-HT concentration in the brains of mice.

๐Ÿ“œ SIMILAR VOLUMES

Effects of 5,7-dihydroxytryptamine and 6
Effects of 5,7-dihydroxytryptamine and 6-hydroxydopamine on head-twitch response induced by serotonin,p-chloroamphetamine, and tryptamine in mice
โœ Shuzo Orikasa; Brian Duff Sloley ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer ๐ŸŒ English โš– 694 KB

Head-twitch response (HTR) in mice was induced by intracerebroventricular injection of tryptamine (TRA) as well as serotonin (5-HT) and p-chloroamphetamine (PCA). Pretreatment with 5,7-dihydroxytryptamine enhanced both the 5-HT-induced and the TRA-induced HTR. The PCA-induced HTR, however, was atten