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Effects of Aminoguanidine and Cyclooxygenase Inhibitors on Nitric Oxide and Prostaglandin Production, and Nitric Oxide Synthase and Cyclooxygenase Expression Induced by Lipopolysaccharide in the Estrogenized Rat Uterus

✍ Scribed by Ribeiro, María; Cella, Maximiliano; Farina, Mariana; Franchi, Ana

Book ID: 120509684
Publisher: S. Karger AG
Year: 2004
Tongue: English
Weight: 123 KB
Volume: 11
Category: Article
ISSN: 1021-7401
DOI: 10.1159/000076768

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Prostaglandins and nitric oxide (NO) are among the numerous substances released by activated microglial cells, the brain resident macrophages, and they mediate several important microglial functions. We have previously shown that cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS), the two key