Effects of aging on spatial learning and hippocampal protein kinase c in mice
β Scribed by Whner, J.M.; Fordyce, D.E.
- Book ID
- 123281351
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 947 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0197-4580
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## Abstract Ageβrelated decline in human cognition is well known, and there are correlative changes in the function of neocortical and hippocampal neurons. Similarly, ageβrelated decline in learning has been observed in rodents, including deficits in a hippocampalβdependent learning paradigm, the M
Protein kinase C (PKC) is highly concentrated in the hippocampus and is thus a possible neural substrate of learning and memory. This study was designed to determine whether partial acquisition (i.e., the minimal amount of training leading to above-chance performance) of a spatial discrimination in