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Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans

✍ Scribed by Roforth, Matthew M.; Fujita, Koji; McGregor, Ulrike I.; Kirmani, Salman; McCready, Louise K.; Peterson, James M.; Drake, Matthew T.; Monroe, David G.; Khosla, Sundeep

Book ID
121414628
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
665 KB
Volume
59
Category
Article
ISSN
8756-3282

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Sclerostin is a potent inhibitor of Wnt signaling and bone formation. However, there is currently no information on the relation of circulating sclerostin levels to age, gender, or bone mass in humans. Thus we measured serum sclerostin levels in a population-based sample of 362 women [123 premenopau