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Effects of administration of dopamine and l-DOPA to dogs on their plasma level of dopamine sulfate

✍ Scribed by Motoo Oka; Yasuko Ishimura; Takeo Tsunematsu; Kazuo Minakuchi; Takeshi Ohuchi; Keizo Matsumoto


Book ID
115779958
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
432 KB
Volume
36
Category
Article
ISSN
0006-2952

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The effect of carbidopa on plasma and mu
✍ S. Rose; P. Jenner; Prof. C. D. Marsden πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 518 KB

Administration of L-dopa (L-3,4-dihydroxyphenylalanine) (200 mg/kg p.o.) to rats produced elevated plasma and muscle concentrations of both L-dopa and 3-O-methyldopa (3-OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg/kg p.o.). Both L-dopa and 3-OMD accumulated in