Positron emission tomography was used to examine the in vivo binding of [ 11 C]raclopride to D 2 -dopamine (DA) receptors in the striatum of two Cynomolgus monkeys after a single dose of reserpine (1 mg/kg, i.v.). A Scatchard procedure was repeated five times to follow D 2 receptor density and appar
Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain
β Scribed by Paul Cumming; Pedro Rosa-Neto; Hideaki Watanabe; Donald Smith; Dirk Bender; Paul B.S Clarke; Albert Gjedde
- Book ID
- 119586044
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 266 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1053-8119
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The selective D2-dopamine receptor antagonist raclopride and its pharmacologically inactive (R)-enantiomer FLB472 were labelled with 11C and used in a study with positron emission tomography to examine the stereoselectivity of 11C-raclopride binding to central D2-dopamine receptors in three healthy
The eect of acute oral ethanol intake (1 . 0 g/kg) on cerebral D2-receptors ([ 11 C]raclopride binding) was studied in seven healthy volunteers, using water and alcohol in two separate 59-min PET sessions. In the alcohol experiments, the blood ethanol concentration at the beginning of the imaging wa
## Abstract The D~2~ receptors exist in either the highβ or lowβaffinity state with respect to agonists, and while agonists bind preferentially to the highβaffinity state, antagonists do not distinguish between the two states. [^11^C]β(+)βPHNO is a PET D~2~ __agonist__ radioligand and therefore pro