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Effects of ACAT inhibitors HL-004 and CI-976 on the synthesis and secretion of esterified cholesterol and on the de novo synthesis of cholesterol and glycerolipids in HepG2 cells

โœ Scribed by Yanagita, T.; Sonda, K.; Yotumoto, H.; Yamamoto, K.; Murakami, S.


Book ID
123136582
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
158 KB
Volume
109
Category
Article
ISSN
0021-9150

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Effect of the ACAT inhibitor CI-976 on p
โœ Brian R. Krause; Richard F. Bousley; Karen A. Kieft; Richard L. Stanfield ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 724 KB

The overall objective of the present study was to determine if the ACAT inhibitor CI-976 can lower plasma cholesterol in hamsters fed zero or low, "human-like" levels of cholesterol. With a purified diet containing zero dietary cholesterol, CI-976 significantly lowered VLDL cholesterol (VLDL-C), but