✦ LIBER ✦

Effects of a sialoglycopeptide on early events associated with signal transduction

✍ Scribed by W. E. Toole-Simms; D. K. Loder; H. K. Fattaey; T. C. Johnson

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 640 KB
Volume: 147
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041470214

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A sialoglycopeptide (SGP), isolated and purified from bovine cerebral cortex cells, was studied in regard to early signal transduction events associated with the cell cycle. Previously shown to be a potent antagonist to a variety of mitogens, the SGP abrogated the ability of 12‐O‐tetradecanoylphorbol‐13 acetate (TPA) to elicit an alkalinization of 3T3 cell cytosol, but only when added minutes prior to, or simultaneously with, the tumor promoter. 3T3 cell TPA‐mediated Ca^2+^ mobilization was also inhibited by the SGP although the inhibitor itself did not bind Ca^2+^ in a cell‐free assay. The results are discussed in light of the already known kinetics of interaction between the SGP, various mitogens, and the calcium ionophore A23187 with regard to the pivotal events leading to the decision of a cell to divide or not to divide.

📜 SIMILAR VOLUMES

Effects of cell cycle status on early ev

Effects of cell cycle status on early events in retroviral replication

✍ Richard A. Katz; James G. Greger; Anna Marie Skalka 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB 👁 1 views

## Abstract The study of retroviruses over the last century has revealed a wide variety of disease‐producing mechanisms, as well as apparently harmless interactions with animal hosts. Despite their potential pathogenic properties, the intrinsic features of retroviruses have been harnessed to create

Synergistic anti-tumoral effect of pacli

Synergistic anti-tumoral effect of paclitaxel (taxol)+AS101 in a murine model of B16 melanoma: Association with ras-dependent signal-transduction pathways

✍ Yona Kalechman; Dan L. Longo; Raphael Catane; Adi Shani; Michael Albeck; Benjami 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 206 KB

Optimal doses of paclitaxel (Taxol) combined with the immunomodulator AS101, previously shown to have antitumoral effects, administered to B16 melanoma-bearing mice decreased tumor volume and resulted in over 60% cure. Paclitaxel؉AS101 directly inhibited the clonogenicity of B16 melanoma cells in a

Effect of hyperthermia in combination wi

Effect of hyperthermia in combination with TRAIL on the JNK-Bim signal transduction pathway and growth of xenograft tumors

✍ Marco A. Alcala Jr.; Kyungsoo Park; Jinsang Yoo; Dae-Hee Lee; Bae-hang Park; Bye 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 385 KB 👁 1 views

## Abstract Approximately 25% of patients with colorectal cancer develop metastases to the liver, and surgery is currently the best treatment available. But there are several patients who are unresectable, and isolated hepatic perfusion (IHP) offers a different approach in helping to treat these pa

Phenomenal characteristics associated wi

Phenomenal characteristics associated with real and imagined events: the effects of event valence and absorption

✍ Lisa M. Destun; Nicholas A. Kuiper 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB

This study examined the eects of emotional valence of an event and individual dierences in absorption on the phenomenal characteristics associated with real and imagined events. Each participant described four events. Two of these were real and two were imagined, with one pleasant and stressful even

Ability to delay neuropathological event

Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: Implications for early intervention on disease progression

✍ Almas Siddiqui; Jyothi K. Mallajosyula; Anand Rane; Julie K. Andersen 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 470 KB

Prevention of spinal motor neuron death

Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SODG93A transgenic mice

✍ Hisashi Narai; Isao Nagano; Hristeina Ilieva; Mito Shiote; Tetsuya Nagata; Takes 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 921 KB

The role of insulin-like growth factor-1 (IGF-1) in amyotrophic lateral sclerosis (ALS) and its mechanism of action are important from both pathogenic and therapeutic points of view. The present study investigated the changes of IGF-1Rb and the key intracellular downstream protein insulin receptor s