We examined the effect of consumption of graded increases of dietary fiber (soft white wheat bran) on the development of mammary gland carcinomas in intact female Sprague-Dawley rats during the promotion stage of carcinogenesis, induced with 7,12-dimethylbenz(a)anthracene (DMBA). The percent of rats
Effects of a norethynodrel-mestranol combination (Enovid) on development and growth of carcinogen-induced mammary tumors in female rats
โ Scribed by Clifford W. Welsch; Joseph Meites
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 780 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0008-543X
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## Abstract The association between a highโfat diet and breast cancer risk is controversial. We hypothesized that the exposure of rats to a highโfat diet __in utero__ __via__ the maternal diet would result in a greater risk of carcinogenโinduced mammary tumors than highโfat diet exposure in postnat
The novel anti-estrogen EM-800 and medroxyprogesterone acetate (MPA) inhibit estrone (E 1 )-stimulated growth of dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in a rat model. After 65 days, ovariectomy (OVX) decreased total tumor area to 9.6 ุ 3.9% of initial size, while E 1 (1.0 ยตg, s.c.,