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Effects of a Formulary Change from Granulocyte Colony-Stimulating Factor to Granulocyte-Macrophage Colony-Stimulating Factor on Outcomes in Patients Treated with Myelosuppressive Chemotherapy

✍ Scribed by Siu-Fun Wong; Holly O. Chan

Book ID
115049115
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
87 KB
Volume
25
Category
Article
ISSN
0277-0008

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GM-CSF is a major regulator of myelopoiesis. Recombinant human GM-CSF (250 micrograms/m2 per day i.v.) was used prior to chemotherapy ("3 + 7" scheme) to recruit leukemic blasts in vivo (de novo AML patients, n = 20) into the chemotherapy sensitive phases of the cell cycle. The stimulatory effect of