Effects of 6-aminonicotinamide on cell growth, poly(ADP-ribose) synthesis and nucleotide metabolism
โ Scribed by Darel Hunting; Bonnie Gowans; J.Frank Henderson
- Book ID
- 115778302
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 601 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0006-2952
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract The effect of nicotinamide on unscheduled DNA synthesis was studied in resting human lymphocytes. In cells treated with UV irradiation or with MNNG, nicotinamide caused a twoโfold stimulation of unscheduled DNA synthesis and retarded the rate of NAD^+^ lowering caused by these treatment
Poly(ADP-ribose) polymerase (PARP) is a DNA-bind-induced apoptosis. After VP16 treatment with PARP ing protein involved in cellular response to various inhibition, a reduction in the depletion of the prolifgenotoxic agents. To understand the role of PARP erative compartment and a G2/M phase arrest a
We report on the individual and combined effects of doxorubicin (DOX) and hyperthermia (HYP) on nucleoid sedimentation and poly (ADP-ribose) polymerase (PARP) activity of L1210 cells. The effects of HYP and DOX on nucleoid sedimentation (increased sedimentation) were similar and correlated with cell