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Effects of 5-HT1A receptor ligands on a safety signal withdrawal procedure of conflict in the rat

✍ Scribed by Dominique Charrier; Laure Dangoumau; Michel Hamon; Alain J. Puech; Marie-Hélène Thiébot

Book ID
113226455
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
850 KB
Volume
48
Category
Article
ISSN
0091-3057

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✍ G. M. Goodwin; Rosemarie J. Souza; A. R. Green 📂 Article 📅 1986 🏛 Springer 🌐 English ⚖ 557 KB

The effects of 2-(4-(4-(2-pyrimidinyl)-l-piperazinyl)-butyl)-1,2-benzoisothiazol-3(2H)one-1,1-dioxide hydrochloride (isapirone, TVX Q 7821), a putative 5-HT1 receptor antagonist, has been studied on various models of 5-HT receptor sub-type function. In mice TVX Q 7821 produced a dose-dependent inhib