Effects of 4-dimethylaminophenol and Co2EDTA on circulation, respiration, and blood homeostasis in dogs

✍ Scribed by R. Klimmek; H. Fladerer; L. Szinicz; N. Weger; M. Kiese

• Publisher: Springer-Verlag
• Year: 1978
• Tongue: English
• Weight: 541 KB
• Volume: 42
• Category: Article
• ISSN: 0340-5761
• DOI: 10.1007/bf00351826

✦ Synopsis

The effects of intravenously injected 4-dimethylaminophenol and COEEDTA on peripheral circulation, respiration, acid-base balance, and several other physiological and biochemical parameters were studied on dogs. DMAP increased the respiratory minute volume and mean arterial pressure, diminished the lactate-to-pyruvate ratio, and induced an increase in arterial oxygen pressure caused by liberation of oxygen from oxyhemoglobin during the formation of ferrihemoglobin.

A study in vitro of the fate of the oxygen during the reaction between DMAP and oxyhemoglobin showed that only 30-40% of the oxygen released by the formation of ferrihemoglobin appeared in the gas phase.

Co2EDTA caused circulatory depression, hyperventilation, and metabolic acidosis resulting in a decrease in base-excess and pH. The concentrations of lactate, pyruvate, potassium, and urea nitrogen and the hemoglobin content were increased by COEEDTA. The side effects of C%EDTA in therapeutic doses were more serious than those of DMAP. Thus the latter is superior in the therapy of cyanide poisoning, all the more since it detoxifies more cyanide.