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Effects of 18α-glycyrrhizin on the pharmacodynamics and pharmacokinetics of glibenclamide in alloxan-induced diabetic rats

✍ Scribed by Ying Ao; Jie Chen; Jiang Yue; Ren-Xiu Peng


Book ID
113587574
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
646 KB
Volume
587
Category
Article
ISSN
0014-2999

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The pharmacokinetic and pharmacodynamic parameters of torasemide were compared after intravenous administration at a dose of 2 mg/kg to diabetic rats induced by alloxan (DMIA) or streptozotocin (DMIS), and their respective control rats. It was reported that torasemide was mainly metabolized via CYP2