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Effects of 1,8-dihydroxyanthraquinone on different segments of rabbit gastrointestinal tract

✍ Scribed by Theodore H. Eickholt; Nolan D. Courville; Lawrence J. Danna; Lynn J. Verzwyvelt; Gerald P. Waguespack

Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
354 KB
Volume
58
Category
Article
ISSN
0022-3549

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✦ Synopsis

Using an isolated muscle bath technique, five different segments of the rabbit gastrointestinal tract (duodenum, jejunum, ileum, ascending and descending colon) were used to record the effects of two doses of 1,s-dihydroxyanthraquinone (danthron). Transducerrecorded tracings were made of contractions per minute, interval between contractions, and amplitude of contractions. The results were evaluated and statistical tests among comparisons of the three parameters between the two drug doses and control values indicated the parameter of interval between contractions to be a statistically significant indication of activity.

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