Effects of 1,3-chelation induced by cis-diamminedichloroplatinum(II) on the stability of DNA duplexes
β Scribed by Hidehito Urata; Masahiro Tamura; Masayuki Urata; Masao Akagi
- Book ID
- 115926791
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 254 KB
- Volume
- 311
- Category
- Article
- ISSN
- 0014-5793
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## Abstract Phenanthreneβ1,2βdimethanol was incorporated into oligodeoxynucleotides __via__ formation of phosphodiester bonds (__cf. Schemeβ 1__). If placed at internal positions in a DNA duplex, a strong reduction of duplex stability is observed (__Tableβ 1__). Terminal attachment of stretches of ph
The combination of cis-diamminedichloroplatinum(ll) (CDDP) and 7-ethyl-I0-[4-( I -pipmidino)-I -piperidino]carbonyloxycamptothecin (CPT-I I), a topoisomerase-I inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To eluc