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Effects induced by BC 264, a selective agonist of CCK-B receptors, on morphine-dependent rats

✍ Scribed by R. Maldonado; O. Valverde; M. Derrien; P. Tejedor-Real; B.P. Roques

Book ID
113226466
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
679 KB
Volume
48
Category
Article
ISSN
0091-3057

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Investigation of behavioral and electrop
Investigation of behavioral and electrophysiological responses induced by selective stimulation of CCKB receptors by using a new highly potent CCK analog, BC 264
✍ V. Dauge; G. A. Bohme; J. N. Crawley; C. Durieux; J. M. Stutzmann; J. Feger; J. πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 926 KB

The new CCKB analog, Boc-Tyr (S0,H)-gNle-mGly-Trp-(NMe)-Nle-Asp-PheNHJBC 264) exhibited a high affinity (KI = 0.39 2 0.15 nM) and selectivity for central (B) versus peripheral (A) receptors (KI CCKAKI CCKB = 910) in the rat. In agreement with these binding studies, BC 264 was a t least 50 times more