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Effects in live cells of a c-myc anti-gene PNA linked to a nuclear localization signal

โœ Scribed by Boffa, Lidia C.; Cutrona, Giovanna; Carpaneto, Elisabetta M.; Ulivi, Massimo; Roncella, Silvio; Landt, Olfert; Ferrarini, Manlio


Book ID
109827843
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
375 KB
Volume
18
Category
Article
ISSN
1087-0156

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## Small -cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often