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Effects and Binding of Insulin-Like Growth Factor I in the Isolated Soleus Muscle of Lean and Obese Mice: Comparison with Insulin*

✍ Scribed by POGGI, CLAIRE; MARCHAND-BRUSTEL, YANNICK LE; ZAPF, JÜRGEN; RUDOLF, FROESCH E.; FREYCHET, PIERRE


Book ID
120624546
Publisher
Endocrine Society
Year
1979
Tongue
English
Weight
895 KB
Volume
105
Category
Article
ISSN
0013-7227

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Binding and growth promoting effects of insulin, insulin analogues modified in the B chain, proinsulin, insulin-like growth factor-I and -II were studied in cultured rat aortic smooth muscle cells. Specific binding of ~2~I-insulin was 0.9 + 0.2% of total ~25I-insulin added, and the ICs0-value was es