Effectiveness of Vitamin E Protecting against UV-Light — Comparative Testing of the Natural Tocopherols on the Skin of the Hairless Mouse

✍ Scribed by Potokar, M. ;Holtmann, W. ;Werner-Busse, A.

• Publisher: John Wiley and Sons
• Year: 1990
• Weight: 463 KB
• Volume: 92
• Category: Article
• ISSN: 0931-5985
• DOI: 10.1002/lipi.19900921007

✦ Synopsis

The protective action of the natural d-tocopherols d-p, d-y and d-6tocopherol against the damaging effects of light was studied, and compared with that of d-a-tocopherol. The tests were carried out on hairless mice. The extent of edema formation caused by exposure to UV-light was measured as a parameter for skin damage. The effectiveness of the d-tocopherols was determined by subjecting the W-edema inhibition values to a special statistical procedure. It was proved that all natural d-tocopherols inhibit skin edema after skin damage. The following activities were determined in comparison to d-a-tocopherol: d-y-tocopherol 72 Yo, d-p-tocopherol 42 Yo, d-&tocopherol 40%. It was possible to exploit the properties of natural homologues as inhibitors of skin damage caused by exposure to W-light by using them as an auxiliary factor in the treatment of specific skin diseases and photodermatoses.