Effectiveness of treatment with donepezil hydrochloride and changes in regional cerebral blood flow in patients with Alzheimer's disease
β Scribed by Tsunetaka Yoshida; Sangkil Ha-Kawa; Masafumi Yoshimura; Kenji Nobuhara; Toshihiko Kinoshita; Satoshi Sawada
- Book ID
- 107614002
- Publisher
- Springer Japan
- Year
- 2007
- Tongue
- English
- Weight
- 341 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0914-7187
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## Abstract ## Background and Aims Donepezil hydrochloride, a central cholinergic drug, is widely used for improving cognitive decline in Alzheimer's disease (AD). We investigated whether donepezil might affect the lower urinary tract (LUT) function in AD. ## Methods Alzheimer's Disease Assessme
Single photon emission computed tomography was used to measure regional cerebral blood flow in six normal subjects and 12 patients with Parkinson's disease, before and after acute oral administration of levodopa. The drug induced a significant increase in cerebral blood flow both in controls and pat