Effectiveness of radiolabelled antibodies for radio-immunotherapy in a colorectal xenograft model: a comparative study using the linear–quadratic formulation

The effect of radiosensitizers on radio-

The effect of radiosensitizers on radio-immunotherapy, using 131I-Labelled anti-cea antibodies in a human colonic xenograft model

✍ R. Barbara Pedley; Richard H. J. Begent; Joan A. Boden; Robert Boden; Theresa Ad 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 683 KB

Anti-CEA antibodies were used for radio-immunotherapy in an established LS174T colonic xenograft in nude mice. A single IV dose of either I3'I-PK4S (polyclonal) or -A5B7 (monoclonal) antibody produced tumour regression, and sig- nificantly delayed subsequent tumour growth. Administration of a cleari